Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4839717..4840319 Replicon chromosome
Accession NZ_CP098234
Organism Escherichia coli strain ZYB39

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag KFZ69_RS23225 Protein ID WP_000897305.1
Coordinates 4840008..4840319 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KFZ69_RS23220 Protein ID WP_000356397.1
Coordinates 4839717..4840007 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFZ69_RS23195 (4835643) 4835643..4836545 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
KFZ69_RS23200 (4836542) 4836542..4837177 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
KFZ69_RS23205 (4837174) 4837174..4838103 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
KFZ69_RS23210 (4838433) 4838433..4838675 - 243 WP_001086388.1 protein YiiF -
KFZ69_RS23215 (4838894) 4838894..4839112 - 219 WP_001297075.1 CopG family transcriptional regulator -
KFZ69_RS23220 (4839717) 4839717..4840007 - 291 WP_000356397.1 NadS family protein Antitoxin
KFZ69_RS23225 (4840008) 4840008..4840319 - 312 WP_000897305.1 hypothetical protein Toxin
KFZ69_RS23230 (4840548) 4840548..4841456 + 909 WP_001162704.1 alpha/beta hydrolase -
KFZ69_RS23235 (4841520) 4841520..4842461 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
KFZ69_RS23240 (4842506) 4842506..4842943 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
KFZ69_RS23245 (4842940) 4842940..4843812 - 873 WP_000920762.1 virulence factor BrkB family protein -
KFZ69_RS23250 (4843806) 4843806..4844405 - 600 WP_001295269.1 glucose-1-phosphatase -
KFZ69_RS23255 (4844504) 4844504..4845289 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T247339 WP_000897305.1 NZ_CP098234:c4840319-4840008 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT247339 WP_000356397.1 NZ_CP098234:c4840007-4839717 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References