Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3850604..3851145 Replicon chromosome
Accession NZ_CP098234
Organism Escherichia coli strain ZYB39

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag KFZ69_RS18670 Protein ID WP_000615976.1
Coordinates 3850867..3851145 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag KFZ69_RS18665 Protein ID WP_000729704.1
Coordinates 3850604..3850864 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFZ69_RS18640 (3846387) 3846387..3847172 - 786 WP_000207568.1 putative lateral flagellar export/assembly protein LafU -
KFZ69_RS18645 (3847144) 3847144..3848856 + 1713 Protein_3651 flagellar biosynthesis protein FlhA -
KFZ69_RS18650 (3848961) 3848961..3849239 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
KFZ69_RS18655 (3849232) 3849232..3849588 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
KFZ69_RS18660 (3849645) 3849645..3850418 - 774 WP_000543899.1 C40 family peptidase -
KFZ69_RS18665 (3850604) 3850604..3850864 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
KFZ69_RS18670 (3850867) 3850867..3851145 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
KFZ69_RS18675 (3851301) 3851301..3852041 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
KFZ69_RS18680 (3852012) 3852012..3852779 - 768 WP_000333380.1 class II glutamine amidotransferase -
KFZ69_RS18685 (3852985) 3852985..3853563 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T247334 WP_000615976.1 NZ_CP098234:3850867-3851145 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT247334 WP_000729704.1 NZ_CP098234:3850604-3850864 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References