Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 654190..654989 Replicon chromosome
Accession NZ_CP098234
Organism Escherichia coli strain ZYB39

Toxin (Protein)


Gene name yhaV Uniprot ID U9XVR9
Locus tag KFZ69_RS03165 Protein ID WP_000347267.1
Coordinates 654190..654654 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag KFZ69_RS03170 Protein ID WP_001307405.1
Coordinates 654654..654989 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFZ69_RS03135 (649191) 649191..649625 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
KFZ69_RS03140 (649643) 649643..650521 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
KFZ69_RS03145 (650511) 650511..651290 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
KFZ69_RS03150 (651301) 651301..651774 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
KFZ69_RS03155 (651797) 651797..653077 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
KFZ69_RS03160 (653326) 653326..654135 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
KFZ69_RS03165 (654190) 654190..654654 - 465 WP_000347267.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
KFZ69_RS03170 (654654) 654654..654989 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
KFZ69_RS03175 (655138) 655138..656709 - 1572 WP_001273741.1 galactarate dehydratase -
KFZ69_RS03180 (657084) 657084..658418 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
KFZ69_RS03185 (658434) 658434..659204 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17807.17 Da        Isoelectric Point: 9.4947

>T247320 WP_000347267.1 NZ_CP098234:c654654-654190 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT247320 WP_001307405.1 NZ_CP098234:c654989-654654 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XTR4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References