Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3798933..3799474 Replicon chromosome
Accession NZ_CP098231
Organism Escherichia coli strain XJ34

Toxin (Protein)


Gene name yafQ Uniprot ID Q32JN3
Locus tag KFZ60_RS18365 Protein ID WP_000615980.1
Coordinates 3799196..3799474 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag KFZ60_RS18360 Protein ID WP_000729704.1
Coordinates 3798933..3799193 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFZ60_RS18340 (3794599) 3794599..3795384 - 786 WP_162859066.1 putative lateral flagellar export/assembly protein LafU -
KFZ60_RS18345 (3795356) 3795356..3797068 + 1713 Protein_3593 flagellar biosynthesis protein FlhA -
KFZ60_RS18350 (3797301) 3797301..3797798 - 498 WP_047625020.1 transposase -
KFZ60_RS18355 (3797974) 3797974..3798723 - 750 WP_024191992.1 C40 family peptidase -
KFZ60_RS18360 (3798933) 3798933..3799193 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
KFZ60_RS18365 (3799196) 3799196..3799474 + 279 WP_000615980.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
KFZ60_RS18370 (3799630) 3799630..3800370 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
KFZ60_RS18375 (3800341) 3800341..3801108 - 768 WP_000333380.1 class II glutamine amidotransferase -
KFZ60_RS18380 (3801230) 3801230..3801808 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(5-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10830.62 Da        Isoelectric Point: 10.0702

>T247307 WP_000615980.1 NZ_CP098231:3799196-3799474 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWLLIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT247307 WP_000729704.1 NZ_CP098231:3798933-3799193 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A090NH48

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References