Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 4105..4964 Replicon plasmid pECL_B
Accession NC_014108
Organism Enterobacter cloacae subsp. cloacae ATCC 13047

Toxin (Protein)


Gene name yhaV Uniprot ID A0A8B3V8K3
Locus tag ECL_RS26965 Protein ID WP_013087279.1
Coordinates 4105..4599 (-) Length 165 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID A0A8B3VF40
Locus tag ECL_RS26970 Protein ID WP_013087280.1
Coordinates 4620..4964 (-) Length 115 a.a.

Genomic Context

ECL_RS26940ECL_RS27015ECL_RS26945ECL_RS26950ECL_RS26955ECL_RS26960ECL_RS26965ECL_RS26970ECL_RS26975ECL_RS26980ECL_RS26985ECL_RS26990ECL_RS26995ECL_RS27000ECL_RS27005ECL_RS27010ECL_RS27020
Location: 1..219 (219 bp)
Type: Others
Protein ID: WP_013087271.1
Location: 8831..9019 (189 bp)
Type: Others
Protein ID: WP_013087290.1
Location: 611..1369 (759 bp)
Type: Others
Protein ID: WP_013087274.1
Location: 1532..2380 (849 bp)
Type: Others
Protein ID: WP_013087275.1
Location: 2570..3250 (681 bp)
Type: Others
Protein ID: WP_013087276.1
Location: 3347..3595 (249 bp)
Type: Others
Protein ID: WP_044160311.1
Location: 4105..4599 (495 bp)
Type: Toxin
Protein ID: WP_013087279.1
Location: 4620..4964 (345 bp)
Type: Antitoxin
Protein ID: WP_013087280.1
Location: 5286..5504 (219 bp)
Type: Others
Protein ID: WP_013087281.1
Location: 5744..5974 (231 bp)
Type: Others
Protein ID: WP_013087283.1
Location: 5965..6228 (264 bp)
Type: Others
Protein ID: WP_013087284.1
Location: 6335..6616 (282 bp)
Type: Others
Protein ID: WP_044160304.1
Location: 6764..7282 (519 bp)
Type: Others
Protein ID: WP_013087286.1
Location: 7272..7646 (375 bp)
Type: Others
Protein ID: WP_044160300.1
Location: 7658..8005 (348 bp)
Type: Others
Protein ID: WP_079972020.1
Location: 8034..8465 (432 bp)
Type: Others
Protein ID: WP_013087289.1
Location: 9282..9719 (438 bp)
Type: Others
Protein ID: WP_013087292.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ECL_RS269401..219+219WP_013087271.1hypothetical protein-
ECL_RS26945611..1369-759WP_013087274.1hypothetical protein-
ECL_RS269501532..2380-849WP_013087275.1DUF4942 domain-containing protein-
ECL_RS269552570..3250-681WP_013087276.1hypothetical protein-
ECL_RS269603347..3595-249WP_044160311.1hypothetical protein-
ECL_RS269654105..4599-495WP_013087279.1type II toxin-antitoxin system YhaV family toxinToxin
ECL_RS269704620..4964-345WP_013087280.1type II toxin-antitoxin system PrlF family antitoxinAntitoxin
ECL_RS269755286..5504-219WP_013087281.1AbrB/MazE/SpoVT family DNA-binding domain-containing protein-
ECL_RS269805744..5974-231WP_013087283.1hypothetical protein-
ECL_RS269855965..6228-264WP_013087284.1DUF1380 family protein-
ECL_RS269906335..6616-282WP_044160304.1hypothetical protein-
ECL_RS269956764..7282-519WP_013087286.1hypothetical protein-
ECL_RS270007272..7646-375WP_044160300.1hypothetical protein-
ECL_RS270057658..8005-348WP_079972020.1hypothetical protein-
ECL_RS270108034..8465-432WP_013087289.1antirestriction protein-
ECL_RS270158831..9019+189WP_013087290.1hypothetical protein-
ECL_RS270209282..9719-438WP_013087292.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..8465384653


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(11-147)

Antitoxin

PrlF antitoxin

(16-114)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 19174.06 Da        Isoelectric Point: 8.6417

>T24730 WP_013087279.1 NC_014108:c4599-4105 [Enterobacter cloacae subsp. cloacae ATCC 13047]
MEYLELNGWKICFHKCFLDQIAELAQKVAELKAAKPNEYHKKKETKLLIAIERVIEEWIASDPLNPQYRQGDTLGDEYKH
WFRVKFLQQFRLFYRCSQEHKTIIIGWVNDFDTLRAYGSKTDAYKVFAEMLKAGTPPDDWNTLLNAAKKATATNTIPGFL
TRQP

Download         Length: 495 bp

>T24730 NC_014108:c4599-4105 [Enterobacter cloacae subsp. cloacae ATCC 13047]
ATGGAATACTTAGAATTAAATGGTTGGAAAATCTGCTTTCACAAATGCTTTTTAGACCAGATTGCGGAGCTTGCGCAGAA
GGTTGCTGAGTTAAAAGCAGCAAAACCCAACGAATACCATAAGAAAAAAGAAACAAAACTCCTGATTGCGATTGAGCGAG
TGATTGAGGAATGGATTGCTTCAGATCCGCTCAATCCACAGTACCGCCAGGGCGACACTTTAGGCGACGAGTACAAACAC
TGGTTCCGGGTAAAATTTTTGCAGCAGTTCCGCTTGTTTTACCGTTGCAGTCAGGAGCACAAAACCATCATTATCGGTTG
GGTTAATGATTTCGATACGCTCCGCGCTTACGGCTCTAAAACGGATGCATATAAAGTGTTTGCGGAAATGCTGAAAGCAG
GTACTCCACCGGATGACTGGAACACACTTCTCAACGCGGCAAAAAAAGCCACGGCCACAAACACTATTCCAGGATTTCTC
ACCAGGCAACCCTAA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 12515.27 Da        Isoelectric Point: 4.4335

>AT24730 WP_013087280.1 NC_014108:c4964-4620 [Enterobacter cloacae subsp. cloacae ATCC 13047]
MATQMLNSADVSLRAESRLTERSQTTIPAAIRDALHLKPGESIHYTLLAGGKVIMSKKEEEQDDPVVPQFLAFLENDMKK
NPQNIAPVPALFWESIKALTAGVEVDLDAPLTDD

Download         Length: 345 bp

>AT24730 NC_014108:c4964-4620 [Enterobacter cloacae subsp. cloacae ATCC 13047]
ATGGCTACTCAAATGTTAAATAGTGCGGACGTGTCACTGCGCGCTGAGTCTCGGCTCACCGAACGCAGCCAGACTACGAT
TCCGGCAGCAATACGCGATGCTTTGCATCTCAAGCCAGGTGAGTCCATTCACTATACCTTGCTTGCGGGCGGTAAAGTCA
TCATGTCTAAAAAGGAAGAAGAACAGGACGATCCAGTTGTTCCACAGTTCCTGGCTTTTCTGGAAAACGACATGAAGAAA
AACCCTCAGAATATTGCCCCTGTTCCGGCTCTGTTCTGGGAAAGCATCAAAGCTTTGACTGCTGGAGTTGAAGTTGATTT
AGACGCGCCGCTTACCGATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A8B3V8K3

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A8B3VF40

References