Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4644196..4644798 Replicon chromosome
Accession NZ_CP098229
Organism Escherichia coli strain XJ55

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag KFZ57_RS22640 Protein ID WP_000897305.1
Coordinates 4644487..4644798 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KFZ57_RS22635 Protein ID WP_000356397.1
Coordinates 4644196..4644486 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFZ57_RS22610 (4640121) 4640121..4641023 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
KFZ57_RS22615 (4641020) 4641020..4641655 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
KFZ57_RS22620 (4641652) 4641652..4642581 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
KFZ57_RS22625 (4642911) 4642911..4643153 - 243 WP_001087409.1 protein YiiF -
KFZ57_RS22630 (4643373) 4643373..4643591 - 219 WP_001315930.1 CopG family transcriptional regulator -
KFZ57_RS22635 (4644196) 4644196..4644486 - 291 WP_000356397.1 NadS family protein Antitoxin
KFZ57_RS22640 (4644487) 4644487..4644798 - 312 WP_000897305.1 hypothetical protein Toxin
KFZ57_RS22645 (4645027) 4645027..4645935 + 909 WP_001162704.1 alpha/beta hydrolase -
KFZ57_RS22650 (4645999) 4645999..4646940 - 942 WP_157913650.1 fatty acid biosynthesis protein FabY -
KFZ57_RS22655 (4646985) 4646985..4647422 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
KFZ57_RS22660 (4647419) 4647419..4648291 - 873 WP_000920762.1 virulence factor BrkB family protein -
KFZ57_RS22665 (4648285) 4648285..4648884 - 600 WP_001295269.1 glucose-1-phosphatase -
KFZ57_RS22670 (4648983) 4648983..4649768 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T247289 WP_000897305.1 NZ_CP098229:c4644798-4644487 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT247289 WP_000356397.1 NZ_CP098229:c4644486-4644196 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References