Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3822302..3822843 Replicon chromosome
Accession NZ_CP098229
Organism Escherichia coli strain XJ55

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag KFZ57_RS18830 Protein ID WP_000615976.1
Coordinates 3822565..3822843 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag KFZ57_RS18825 Protein ID WP_000729704.1
Coordinates 3822302..3822562 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFZ57_RS18800 (3818085) 3818085..3818870 - 786 WP_000207575.1 putative lateral flagellar export/assembly protein LafU -
KFZ57_RS18805 (3818842) 3818842..3820554 + 1713 Protein_3684 flagellar biosynthesis protein FlhA -
KFZ57_RS18810 (3820659) 3820659..3820937 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
KFZ57_RS18815 (3820930) 3820930..3821286 + 357 WP_001030483.1 type II toxin-antitoxin system HicB family antitoxin -
KFZ57_RS18820 (3821343) 3821343..3822116 - 774 WP_122988366.1 C40 family peptidase -
KFZ57_RS18825 (3822302) 3822302..3822562 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
KFZ57_RS18830 (3822565) 3822565..3822843 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
KFZ57_RS18835 (3822999) 3822999..3823739 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
KFZ57_RS18840 (3823710) 3823710..3824477 - 768 WP_000333380.1 class II glutamine amidotransferase -
KFZ57_RS18845 (3824683) 3824683..3825261 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - gmhA/lpcA / rhs/PAAR 3820930..3838829 17899


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T247285 WP_000615976.1 NZ_CP098229:3822565-3822843 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT247285 WP_000729704.1 NZ_CP098229:3822302-3822562 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References