247274

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1889845..1890347 Replicon chromosome
Accession NZ_CP098229
Organism Escherichia coli strain XJ55

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag KFZ57_RS09095 Protein ID WP_000767829.1
Coordinates 1890093..1890347 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag KFZ57_RS09090 Protein ID WP_001259255.1
Coordinates 1889845..1890096 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFZ57_RS09065 (1885023) 1885023..1886090 - 1068 WP_000080085.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
KFZ57_RS09070 (1886090) 1886090..1887160 - 1071 WP_000108967.1 histidinol-phosphate transaminase -
KFZ57_RS09075 (1887157) 1887157..1888461 - 1305 WP_001593467.1 histidinol dehydrogenase -
KFZ57_RS09080 (1888467) 1888467..1889366 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
KFZ57_RS09085 (1889512) 1889512..1889562 - 51 WP_001364200.1 his operon leader peptide -
KFZ57_RS09090 (1889845) 1889845..1890096 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
KFZ57_RS09095 (1890093) 1890093..1890347 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
KFZ57_RS09100 (1890430) 1890430..1891254 + 825 WP_000754758.1 SDR family oxidoreductase -
KFZ57_RS09105 (1891300) 1891300..1892229 + 930 WP_000803370.1 LysR substrate-binding domain-containing protein -
KFZ57_RS09110 (1892444) 1892444..1892506 + 63 WP_010723108.1 membrane protein YoeI -
KFZ57_RS09115 (1892496) 1892496..1893854 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
KFZ57_RS09120 (1894033) 1894033..1895091 + 1059 WP_000492346.1 thiosulfate utilization transporter TsuA/YeeE -
KFZ57_RS09125 (1895105) 1895105..1895332 + 228 WP_000985270.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T247274 WP_000767829.1 NZ_CP098229:1890093-1890347 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT247274 WP_001259255.1 NZ_CP098229:1889845-1890096 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References