Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 625144..625943 Replicon chromosome
Accession NZ_CP098229
Organism Escherichia coli strain XJ55

Toxin (Protein)


Gene name yhaV Uniprot ID F4VJD3
Locus tag KFZ57_RS03025 Protein ID WP_000347266.1
Coordinates 625144..625608 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag KFZ57_RS03030 Protein ID WP_001307405.1
Coordinates 625608..625943 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFZ57_RS02995 (620145) 620145..620579 - 435 WP_074520084.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
KFZ57_RS03000 (620597) 620597..621475 - 879 WP_001315856.1 PTS N-acetylgalactosamine transporter subunit IID -
KFZ57_RS03005 (621465) 621465..622244 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
KFZ57_RS03010 (622255) 622255..622728 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
KFZ57_RS03015 (622751) 622751..624031 - 1281 WP_275801508.1 tagatose-bisphosphate aldolase subunit KbaZ -
KFZ57_RS03020 (624280) 624280..625089 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
KFZ57_RS03025 (625144) 625144..625608 - 465 WP_000347266.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
KFZ57_RS03030 (625608) 625608..625943 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
KFZ57_RS03035 (626092) 626092..627663 - 1572 WP_001273741.1 galactarate dehydratase -
KFZ57_RS03040 (628038) 628038..629372 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
KFZ57_RS03045 (629388) 629388..630158 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 625144..638210 13066


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17841.18 Da        Isoelectric Point: 9.4947

>T247269 WP_000347266.1 NZ_CP098229:c625608-625144 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRFFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT247269 WP_001307405.1 NZ_CP098229:c625943-625608 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A836NGD2

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References