Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 4128495..4128907 Replicon chromosome
Accession NZ_CP098227
Organism Escherichia coli strain XJ6-3

Toxin (Protein)


Gene name symE Uniprot ID U9YSY7
Locus tag KFZ54_RS19900 Protein ID WP_000132601.1
Coordinates 4128566..4128907 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 4128495..4128571 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFZ54_RS19890 (4125358) 4125358..4126947 + 1590 WP_001063204.1 type I restriction-modification system methyltransferase -
KFZ54_RS19895 (4126944) 4126944..4128338 + 1395 WP_001272447.1 type I restriction-modification system specificity subunit -
- (4128495) 4128495..4128571 - 77 NuclAT_13 - Antitoxin
- (4128495) 4128495..4128571 - 77 NuclAT_13 - Antitoxin
- (4128495) 4128495..4128571 - 77 NuclAT_13 - Antitoxin
- (4128495) 4128495..4128571 - 77 NuclAT_13 - Antitoxin
- (4128495) 4128495..4128571 - 77 NuclAT_14 - Antitoxin
- (4128495) 4128495..4128571 - 77 NuclAT_14 - Antitoxin
- (4128495) 4128495..4128571 - 77 NuclAT_14 - Antitoxin
- (4128495) 4128495..4128571 - 77 NuclAT_14 - Antitoxin
KFZ54_RS19900 (4128566) 4128566..4128907 + 342 WP_000132601.1 endoribonuclease SymE Toxin
KFZ54_RS19905 (4129069) 4129069..4130448 + 1380 WP_000443951.1 5-methylcytosine-specific restriction endonuclease subunit McrB -
KFZ54_RS19910 (4130448) 4130448..4131494 + 1047 WP_000437621.1 5-methylcytosine-specific restriction endonuclease system specificity protein McrC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4126944..4137193 10249


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12203.02 Da        Isoelectric Point: 8.5012

>T247263 WP_000132601.1 NZ_CP098227:4128566-4128907 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Download         Length: 342 bp

Antitoxin


Download         Length: 77 bp

>AT247263 NZ_CP098227:c4128571-4128495 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YSY7

Antitoxin

Download structure file

References