Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3798948..3799489 Replicon chromosome
Accession NZ_CP098227
Organism Escherichia coli strain XJ6-3

Toxin (Protein)


Gene name yafQ Uniprot ID Q32JN3
Locus tag KFZ54_RS18355 Protein ID WP_000615980.1
Coordinates 3799211..3799489 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag KFZ54_RS18350 Protein ID WP_000729704.1
Coordinates 3798948..3799208 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFZ54_RS18330 (3794614) 3794614..3795399 - 786 WP_162859066.1 putative lateral flagellar export/assembly protein LafU -
KFZ54_RS18335 (3795371) 3795371..3797083 + 1713 Protein_3591 flagellar biosynthesis protein FlhA -
KFZ54_RS18340 (3797316) 3797316..3797813 - 498 WP_047625020.1 transposase -
KFZ54_RS18345 (3797989) 3797989..3798738 - 750 WP_024191992.1 C40 family peptidase -
KFZ54_RS18350 (3798948) 3798948..3799208 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
KFZ54_RS18355 (3799211) 3799211..3799489 + 279 WP_000615980.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
KFZ54_RS18360 (3799645) 3799645..3800385 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
KFZ54_RS18365 (3800356) 3800356..3801123 - 768 WP_000333380.1 class II glutamine amidotransferase -
KFZ54_RS18370 (3801245) 3801245..3801823 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(5-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10830.62 Da        Isoelectric Point: 10.0702

>T247261 WP_000615980.1 NZ_CP098227:3799211-3799489 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWLLIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT247261 WP_000729704.1 NZ_CP098227:3798948-3799208 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A090NH48

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References