Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2407360..2407922 Replicon chromosome
Accession NZ_CP098227
Organism Escherichia coli strain XJ6-3

Toxin (Protein)


Gene name higB Uniprot ID L4J948
Locus tag KFZ54_RS11660 Protein ID WP_000605676.1
Coordinates 2407360..2407638 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag KFZ54_RS11665 Protein ID WP_000781370.1
Coordinates 2407638..2407922 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFZ54_RS11635 (2402946) 2402946..2403377 - 432 WP_032280863.1 peroxiredoxin OsmC -
KFZ54_RS11640 (2403723) 2403723..2403938 + 216 WP_000495766.1 biofilm-dependent modulation protein -
KFZ54_RS11645 (2404040) 2404040..2404177 + 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
KFZ54_RS11650 (2404333) 2404333..2406030 + 1698 WP_088376254.1 malate dehydrogenase -
KFZ54_RS11655 (2406164) 2406164..2407174 + 1011 WP_088376255.1 alcohol dehydrogenase AdhP -
KFZ54_RS11660 (2407360) 2407360..2407638 + 279 WP_000605676.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KFZ54_RS11665 (2407638) 2407638..2407922 + 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
KFZ54_RS11670 (2408150) 2408150..2408803 - 654 WP_000045648.1 formate dehydrogenase-N subunit gamma -
KFZ54_RS11675 (2408796) 2408796..2409680 - 885 WP_001240582.1 formate dehydrogenase N subunit beta -
KFZ54_RS11680 (2409693) 2409693..2412740 - 3048 WP_012767733.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10521.10 Da        Isoelectric Point: 7.3562

>T247255 WP_000605676.1 NZ_CP098227:2407360-2407638 [Escherichia coli]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT247255 WP_000781370.1 NZ_CP098227:2407638-2407922 [Escherichia coli]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829G6T1

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References