247247

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 624468..625267 Replicon chromosome
Accession NZ_CP098227
Organism Escherichia coli strain XJ6-3

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag KFZ54_RS03025 Protein ID WP_088376472.1
Coordinates 624468..624932 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag KFZ54_RS03030 Protein ID WP_001307405.1
Coordinates 624932..625267 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFZ54_RS02995 (619469) 619469..619903 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
KFZ54_RS03000 (619921) 619921..620799 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
KFZ54_RS03005 (620789) 620789..621568 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
KFZ54_RS03010 (621579) 621579..622052 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
KFZ54_RS03015 (622075) 622075..623355 - 1281 WP_000681939.1 tagatose-bisphosphate aldolase subunit KbaZ -
KFZ54_RS03020 (623604) 623604..624413 + 810 WP_000072174.1 aga operon transcriptional regulator AgaR -
KFZ54_RS03025 (624468) 624468..624932 - 465 WP_088376472.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
KFZ54_RS03030 (624932) 624932..625267 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
KFZ54_RS03035 (625417) 625417..626988 - 1572 WP_001273763.1 galactarate dehydratase -
KFZ54_RS03040 (627363) 627363..628697 + 1335 WP_097756011.1 galactarate/glucarate/glycerate transporter GarP -
KFZ54_RS03045 (628713) 628713..629483 + 771 WP_021577990.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17835.31 Da        Isoelectric Point: 9.9660

>T247247 WP_088376472.1 NZ_CP098227:c624932-624468 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWKTLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT247247 WP_001307405.1 NZ_CP098227:c625267-624932 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References