Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 4140372..4141171 Replicon chromosome
Accession NZ_CP098223
Organism Escherichia coli strain Z0117EC0005

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag NBY12_RS19775 Protein ID WP_000347251.1
Coordinates 4140707..4141171 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag NBY12_RS19770 Protein ID WP_001296435.1
Coordinates 4140372..4140707 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY12_RS19755 (4136156) 4136156..4136926 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
NBY12_RS19760 (4136942) 4136942..4138276 - 1335 WP_032185178.1 galactarate/glucarate/glycerate transporter GarP -
NBY12_RS19765 (4138652) 4138652..4140223 + 1572 WP_137498661.1 galactarate dehydratase -
NBY12_RS19770 (4140372) 4140372..4140707 + 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
NBY12_RS19775 (4140707) 4140707..4141171 + 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
NBY12_RS19780 (4141226) 4141226..4142035 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
NBY12_RS19785 (4142284) 4142284..4143564 + 1281 WP_032303875.1 tagatose-bisphosphate aldolase subunit KbaZ -
NBY12_RS19790 (4143587) 4143587..4144060 + 474 WP_032303829.1 PTS N-acetylgalactosamine transporter subunit IIB -
NBY12_RS19795 (4144071) 4144071..4144850 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
NBY12_RS19800 (4144840) 4144840..4145718 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
NBY12_RS19805 (4145736) 4145736..4146170 + 435 WP_032303830.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4131582..4141171 9589


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T247236 WP_000347251.1 NZ_CP098223:4140707-4141171 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT247236 WP_001296435.1 NZ_CP098223:4140372-4140707 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References