247202

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 4680722..4682040 Replicon chromosome
Accession NZ_CP098219
Organism Escherichia coli strain Z0117EC0013

Toxin (Protein)


Gene name HipT Uniprot ID F4T5A3
Locus tag NBY13_RS22620 Protein ID WP_001262467.1
Coordinates 4680722..4681729 (-) Length 336 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID F4T5A4
Locus tag NBY13_RS22625 Protein ID WP_001312177.1
Coordinates 4681729..4682040 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY13_RS22590 (4675932) 4675932..4676123 + 192 WP_000988308.1 cellulose biosynthesis protein BcsF -
NBY13_RS22595 (4676120) 4676120..4677799 + 1680 Protein_4412 cellulose biosynthesis protein BcsG -
NBY13_RS22600 (4677885) 4677885..4677992 - 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
NBY13_RS22605 (4678368) 4678368..4678475 - 108 WP_000170748.1 type I toxin-antitoxin system toxin Ldr family protein -
- (4678532) 4678532..4678589 + 58 NuclAT_26 - -
- (4678532) 4678532..4678589 + 58 NuclAT_26 - -
- (4678532) 4678532..4678589 + 58 NuclAT_26 - -
- (4678532) 4678532..4678589 + 58 NuclAT_26 - -
NBY13_RS22610 (4678851) 4678851..4678958 - 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
- (4679007) 4679007..4679072 + 66 NuclAT_27 - -
- (4679007) 4679007..4679072 + 66 NuclAT_27 - -
- (4679007) 4679007..4679072 + 66 NuclAT_27 - -
- (4679007) 4679007..4679072 + 66 NuclAT_27 - -
NBY13_RS22615 (4679434) 4679434..4680705 + 1272 WP_001545666.1 amino acid permease -
NBY13_RS22620 (4680722) 4680722..4681729 - 1008 WP_001262467.1 HipA domain-containing protein Toxin
NBY13_RS22625 (4681729) 4681729..4682040 - 312 WP_001312177.1 HipA N-terminal domain-containing protein Antitoxin
NBY13_RS22630 (4682025) 4682025..4682348 - 324 WP_000563102.1 helix-turn-helix transcriptional regulator -
NBY13_RS22635 (4682573) 4682573..4683586 - 1014 WP_000103572.1 dipeptide ABC transporter ATP-binding subunit DppF -
NBY13_RS22640 (4683583) 4683583..4684566 - 984 WP_001196477.1 dipeptide ABC transporter ATP-binding protein -
NBY13_RS22645 (4684577) 4684577..4685479 - 903 WP_000084677.1 dipeptide ABC transporter permease DppC -
NBY13_RS22650 (4685489) 4685489..4686508 - 1020 WP_000938855.1 dipeptide ABC transporter permease DppB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-302)

Antitoxin

HipA, N-terminal subdomain 1

(6-98)


Sequences

Toxin        


Download         Length: 336 a.a.        Molecular weight: 38320.60 Da        Isoelectric Point: 5.5965

>T247202 WP_001262467.1 NZ_CP098219:c4681729-4680722 [Escherichia coli]
MANCRILLTPLNERDEQRGYSTQGLKRLSGTAKLTPRLGFTRTQFVQELPRQQKGMSISGYQPKLQLVLDEGEFRVVDHQ
GNFILKPSPADFPGLAENEHATMTLMSRLGFDVPVHGLLSFAPQSEEELEYAFVIRRYDRDNKGLPVHQEQLDGAMQIMD
KYGKTGNDNEQYVSYETLARFLVAHVNDNIAFKIDLFRRIVYAWLLGNNDMHLRNFGLVYSDGLTPALAPVYDFVSVAPY
PEYFHSNYLALPLLTREEGGRELAPGFHSDYGEYIGQDFLLLGESMGLAPRLLEKLFQDIRKENAIVMETYEQSFMTQDH
IQAVLQCYRHRLGLL

Download         Length: 1008 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11821.47 Da        Isoelectric Point: 6.0609

>AT247202 WP_001312177.1 NZ_CP098219:c4682040-4681729 [Escherichia coli]
MHRRVKVLLYGQVVGELSQNDSGFLFQYAPDYHGPAISISLPVAQRQFPSEMLHPYFASLAPEGWLRQRYSQIQHRDEND
LLGMLIDNGKNLLGAIQILPWEE

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3K2ZTB5

Antitoxin

Source ID Structure
AlphaFold DB A0A3L3HKE2

References