Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 4264995..4265794 Replicon chromosome
Accession NZ_CP098219
Organism Escherichia coli strain Z0117EC0013

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag NBY13_RS20530 Protein ID WP_000347251.1
Coordinates 4265330..4265794 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag NBY13_RS20525 Protein ID WP_001296435.1
Coordinates 4264995..4265330 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY13_RS20510 (4260780) 4260780..4261550 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
NBY13_RS20515 (4261566) 4261566..4262900 - 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
NBY13_RS20520 (4263275) 4263275..4264846 + 1572 WP_001273763.1 galactarate dehydratase -
NBY13_RS20525 (4264995) 4264995..4265330 + 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
NBY13_RS20530 (4265330) 4265330..4265794 + 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
NBY13_RS20535 (4265849) 4265849..4266658 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
NBY13_RS20540 (4266907) 4266907..4268187 + 1281 WP_000681950.1 tagatose-bisphosphate aldolase subunit KbaZ -
NBY13_RS20545 (4268210) 4268210..4268683 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
NBY13_RS20550 (4268694) 4268694..4269473 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
NBY13_RS20555 (4269463) 4269463..4270341 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
NBY13_RS20560 (4270359) 4270359..4270793 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T247200 WP_000347251.1 NZ_CP098219:4265330-4265794 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT247200 WP_001296435.1 NZ_CP098219:4264995-4265330 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References