Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2977854..2978356 Replicon chromosome
Accession NZ_CP098219
Organism Escherichia coli strain Z0117EC0013

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag NBY13_RS14620 Protein ID WP_000767822.1
Coordinates 2977854..2978108 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag NBY13_RS14625 Protein ID WP_001259255.1
Coordinates 2978105..2978356 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY13_RS14600 (2974347) 2974347..2975705 - 1359 WP_000019194.1 putrescine/proton symporter PlaP -
NBY13_RS14605 (2975695) 2975695..2975757 - 63 WP_010723108.1 membrane protein YoeI -
NBY13_RS14610 (2975972) 2975972..2976901 - 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
NBY13_RS14615 (2976947) 2976947..2977771 - 825 WP_000754737.1 SDR family oxidoreductase -
NBY13_RS14620 (2977854) 2977854..2978108 - 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
NBY13_RS14625 (2978105) 2978105..2978356 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
NBY13_RS14630 (2978639) 2978639..2978689 + 51 WP_001364200.1 his operon leader peptide -
NBY13_RS14635 (2978835) 2978835..2979734 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
NBY13_RS14640 (2979740) 2979740..2981044 + 1305 WP_001546022.1 histidinol dehydrogenase -
NBY13_RS14645 (2981041) 2981041..2982111 + 1071 WP_000108941.1 histidinol-phosphate transaminase -
NBY13_RS14650 (2982111) 2982111..2983178 + 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T247196 WP_000767822.1 NZ_CP098219:c2978108-2977854 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT247196 WP_001259255.1 NZ_CP098219:c2978356-2978105 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References