Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4885399..4886001 Replicon chromosome
Accession NZ_CP098214
Organism Escherichia coli strain Z0117EC0036

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag NBY15_RS23695 Protein ID WP_000897302.1
Coordinates 4885690..4886001 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NBY15_RS23690 Protein ID WP_000356397.1
Coordinates 4885399..4885689 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY15_RS23665 (4881464) 4881464..4882366 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
NBY15_RS23670 (4882363) 4882363..4882998 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
NBY15_RS23675 (4882995) 4882995..4883924 + 930 WP_001553788.1 formate dehydrogenase accessory protein FdhE -
NBY15_RS23680 (4884148) 4884148..4884366 - 219 WP_001314326.1 CopG family transcriptional regulator -
NBY15_RS23685 (4884762) 4884762..4885040 - 279 WP_001296612.1 hypothetical protein -
NBY15_RS23690 (4885399) 4885399..4885689 - 291 WP_000356397.1 NadS family protein Antitoxin
NBY15_RS23695 (4885690) 4885690..4886001 - 312 WP_000897302.1 hypothetical protein Toxin
NBY15_RS23700 (4886231) 4886231..4887139 + 909 WP_001331553.1 alpha/beta hydrolase -
NBY15_RS23705 (4887203) 4887203..4888144 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
NBY15_RS23710 (4888189) 4888189..4888626 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
NBY15_RS23715 (4888623) 4888623..4889495 - 873 WP_000920762.1 virulence factor BrkB family protein -
NBY15_RS23720 (4889489) 4889489..4890088 - 600 WP_001314324.1 glucose-1-phosphatase -
NBY15_RS23725 (4890187) 4890187..4890972 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T247144 WP_000897302.1 NZ_CP098214:c4886001-4885690 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT247144 WP_000356397.1 NZ_CP098214:c4885689-4885399 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References