Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 4211599..4212011 Replicon chromosome
Accession NZ_CP098214
Organism Escherichia coli strain Z0117EC0036

Toxin (Protein)


Gene name symE Uniprot ID S1NWQ7
Locus tag NBY15_RS20620 Protein ID WP_000132614.1
Coordinates 4211670..4212011 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 4211599..4211675 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY15_RS20610 (4208274) 4208274..4209743 + 1470 WP_001540814.1 type I restriction-modification system subunit M -
NBY15_RS20615 (4209743) 4209743..4211449 + 1707 WP_001100194.1 restriction endonuclease subunit S -
- (4211599) 4211599..4211675 - 77 NuclAT_6 - Antitoxin
- (4211599) 4211599..4211675 - 77 NuclAT_6 - Antitoxin
- (4211599) 4211599..4211675 - 77 NuclAT_6 - Antitoxin
- (4211599) 4211599..4211675 - 77 NuclAT_6 - Antitoxin
- (4211599) 4211599..4211675 - 77 NuclAT_7 - Antitoxin
- (4211599) 4211599..4211675 - 77 NuclAT_7 - Antitoxin
- (4211599) 4211599..4211675 - 77 NuclAT_7 - Antitoxin
- (4211599) 4211599..4211675 - 77 NuclAT_7 - Antitoxin
NBY15_RS20620 (4211670) 4211670..4212011 + 342 WP_000132614.1 endoribonuclease SymE Toxin
NBY15_RS20625 (4212058) 4212058..4213221 - 1164 WP_225377659.1 DUF1524 domain-containing protein -
NBY15_RS20630 (4213269) 4213269..4214151 - 883 Protein_4047 DUF262 domain-containing protein -
NBY15_RS20635 (4214557) 4214557..4215477 - 921 WP_000181195.1 Rpn family recombination-promoting nuclease/putative transposase -
NBY15_RS20640 (4215662) 4215662..4216942 + 1281 WP_021520478.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - cheD 4195469..4214214 18745


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12266.07 Da        Isoelectric Point: 8.4982

>T247137 WP_000132614.1 NZ_CP098214:4211670-4212011 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

Antitoxin


Download         Length: 77 bp

>AT247137 NZ_CP098214:c4211675-4211599 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NWQ7

Antitoxin

Download structure file

References