Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 759314..760113 Replicon chromosome
Accession NZ_CP098214
Organism Escherichia coli strain Z0117EC0036

Toxin (Protein)


Gene name yhaV Uniprot ID Q8FDB4
Locus tag NBY15_RS03790 Protein ID WP_000347252.1
Coordinates 759314..759778 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag NBY15_RS03795 Protein ID WP_001296435.1
Coordinates 759778..760113 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY15_RS03760 (754315) 754315..754749 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
NBY15_RS03765 (754767) 754767..755645 - 879 WP_001298314.1 PTS N-acetylgalactosamine transporter subunit IID -
NBY15_RS03770 (755635) 755635..756414 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
NBY15_RS03775 (756425) 756425..756898 - 474 WP_001298322.1 PTS N-acetylgalactosamine transporter subunit IIB -
NBY15_RS03780 (756921) 756921..758201 - 1281 WP_000681923.1 tagatose-bisphosphate aldolase subunit KbaZ -
NBY15_RS03785 (758450) 758450..759259 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
NBY15_RS03790 (759314) 759314..759778 - 465 WP_000347252.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
NBY15_RS03795 (759778) 759778..760113 - 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
NBY15_RS03800 (760262) 760262..761833 - 1572 WP_001273939.1 galactarate dehydratase -
NBY15_RS03805 (762208) 762208..763542 + 1335 WP_000979025.1 galactarate/glucarate/glycerate transporter GarP -
NBY15_RS03810 (763558) 763558..764328 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17750.11 Da        Isoelectric Point: 9.4947

>T247122 WP_000347252.1 NZ_CP098214:c759778-759314 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEESH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT247122 WP_001296435.1 NZ_CP098214:c760113-759778 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q8FDB4

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References