247115

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4684375..4684977 Replicon chromosome
Accession NZ_CP098211
Organism Escherichia coli strain Z0117EC0040

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag NBY16_RS22535 Protein ID WP_000897305.1
Coordinates 4684666..4684977 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NBY16_RS22530 Protein ID WP_000356397.1
Coordinates 4684375..4684665 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY16_RS22505 (4680301) 4680301..4681203 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
NBY16_RS22510 (4681200) 4681200..4681835 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
NBY16_RS22515 (4681832) 4681832..4682761 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
NBY16_RS22520 (4683091) 4683091..4683333 - 243 WP_001086388.1 protein YiiF -
NBY16_RS22525 (4683552) 4683552..4683770 - 219 WP_001295676.1 CopG family transcriptional regulator -
NBY16_RS22530 (4684375) 4684375..4684665 - 291 WP_000356397.1 NadS family protein Antitoxin
NBY16_RS22535 (4684666) 4684666..4684977 - 312 WP_000897305.1 hypothetical protein Toxin
NBY16_RS22540 (4685206) 4685206..4686114 + 909 WP_048963532.1 alpha/beta hydrolase -
NBY16_RS22545 (4686178) 4686178..4687119 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
NBY16_RS22550 (4687164) 4687164..4687601 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
NBY16_RS22555 (4687598) 4687598..4688470 - 873 WP_000920762.1 virulence factor BrkB family protein -
NBY16_RS22560 (4688464) 4688464..4689063 - 600 WP_001295269.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T247115 WP_000897305.1 NZ_CP098211:c4684977-4684666 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT247115 WP_000356397.1 NZ_CP098211:c4684665-4684375 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References