247110

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3838265..3838806 Replicon chromosome
Accession NZ_CP098211
Organism Escherichia coli strain Z0117EC0040

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag NBY16_RS18585 Protein ID WP_000615976.1
Coordinates 3838528..3838806 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag NBY16_RS18580 Protein ID WP_000729704.1
Coordinates 3838265..3838525 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY16_RS18555 (3834048) 3834048..3834833 - 786 WP_000207568.1 putative lateral flagellar export/assembly protein LafU -
NBY16_RS18560 (3834805) 3834805..3836517 + 1713 Protein_3644 flagellar biosynthesis protein FlhA -
NBY16_RS18565 (3836622) 3836622..3836900 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
NBY16_RS18570 (3836893) 3836893..3837249 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
NBY16_RS18575 (3837306) 3837306..3838079 - 774 WP_000543897.1 C40 family peptidase -
NBY16_RS18580 (3838265) 3838265..3838525 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
NBY16_RS18585 (3838528) 3838528..3838806 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
NBY16_RS18590 (3838962) 3838962..3839702 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
NBY16_RS18595 (3839673) 3839673..3840440 - 768 WP_000333380.1 class II glutamine amidotransferase -
NBY16_RS18600 (3840646) 3840646..3841224 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T247110 WP_000615976.1 NZ_CP098211:3838528-3838806 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT247110 WP_000729704.1 NZ_CP098211:3838265-3838525 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6Z6

References