Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 670630..671429 Replicon chromosome
Accession NZ_CP098211
Organism Escherichia coli strain Z0117EC0040

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag NBY16_RS03240 Protein ID WP_000347273.1
Coordinates 670630..671094 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag NBY16_RS03245 Protein ID WP_001307405.1
Coordinates 671094..671429 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY16_RS03210 (665631) 665631..666065 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
NBY16_RS03215 (666083) 666083..666961 - 879 WP_001298758.1 PTS N-acetylgalactosamine transporter subunit IID -
NBY16_RS03220 (666951) 666951..667730 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
NBY16_RS03225 (667741) 667741..668214 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
NBY16_RS03230 (668237) 668237..669517 - 1281 WP_000681921.1 tagatose-bisphosphate aldolase subunit KbaZ -
NBY16_RS03235 (669766) 669766..670575 + 810 WP_000072180.1 aga operon transcriptional regulator AgaR -
NBY16_RS03240 (670630) 670630..671094 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
NBY16_RS03245 (671094) 671094..671429 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
NBY16_RS03250 (671578) 671578..673149 - 1572 WP_048963235.1 galactarate dehydratase -
NBY16_RS03255 (673524) 673524..674858 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
NBY16_RS03260 (674874) 674874..675644 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T247097 WP_000347273.1 NZ_CP098211:c671094-670630 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT247097 WP_001307405.1 NZ_CP098211:c671429-671094 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References