Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1272775..1273502 Replicon chromosome
Accession NZ_CP098210
Organism Escherichia coli strain Z0117EC0051

Toxin (Protein)


Gene name higB Uniprot ID V0YLE2
Locus tag NBY17_RS06005 Protein ID WP_000547555.1
Coordinates 1272775..1273086 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NBY17_RS06010 Protein ID WP_000126294.1
Coordinates 1273083..1273502 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY17_RS05980 (1268710) 1268710..1270419 + 1710 WP_001288122.1 formate hydrogenlyase subunit HycE -
NBY17_RS05985 (1270429) 1270429..1270971 + 543 WP_000493785.1 formate hydrogenlyase subunit HycF -
NBY17_RS05990 (1270971) 1270971..1271738 + 768 WP_000067399.1 formate hydrogenlyase subunit HycG -
NBY17_RS05995 (1271735) 1271735..1272145 + 411 WP_001291918.1 formate hydrogenlyase assembly protein HycH -
NBY17_RS06000 (1272138) 1272138..1272608 + 471 WP_001551542.1 hydrogenase maturation peptidase HycI -
NBY17_RS06005 (1272775) 1272775..1273086 + 312 WP_000547555.1 type II toxin-antitoxin system HigB family toxin Toxin
NBY17_RS06010 (1273083) 1273083..1273502 + 420 WP_000126294.1 helix-turn-helix domain-containing protein Antitoxin
NBY17_RS06015 (1273581) 1273581..1275005 - 1425 WP_000110355.1 6-phospho-beta-glucosidase AscB -
NBY17_RS06020 (1275014) 1275014..1276471 - 1458 WP_001107889.1 PTS cellobiose/arbutin/salicin transporter subunit IIBC -
NBY17_RS06025 (1276731) 1276731..1277741 + 1011 WP_029130985.1 DNA-binding transcriptional regulator AscG -
NBY17_RS06030 (1277890) 1277890..1278417 + 528 WP_001078777.1 electron transport protein HydN -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12439.18 Da        Isoelectric Point: 9.5146

>T247082 WP_000547555.1 NZ_CP098210:1272775-1273086 [Escherichia coli]
MHIISKAPFEECARKYPNDALALHSLYRVIKETDFSTPEEMRTAFPNLDNFKYRNKWYVLDVGGNNLRVIAYINFVNKRF
FVKHITNHAEYDKLTRYYRENKE

Download         Length: 312 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15416.42 Da        Isoelectric Point: 4.4596

>AT247082 WP_000126294.1 NZ_CP098210:1273083-1273502 [Escherichia coli]
MTANAARAVKATRELVNAVPFLGGSDSEDDYREALELVEYLIEEDDTNPLIDFLASRIAEYENNNEKFAEFDKAVAAMPV
GVALLRTLIDQHNLTYADLKNEIGSKSLVSQILSGQRSLTISHIKALSARFGVKPEWFL

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0YLE2

Antitoxin

Source ID Structure

References