Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1085515..1086209 Replicon chromosome
Accession NC_014029
Organism Yersinia pestis Z176003

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0E1NW62
Locus tag YPZ3_RS04915 Protein ID WP_002214787.1
Coordinates 1085515..1085811 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q666X1
Locus tag YPZ3_RS04920 Protein ID WP_002209924.1
Coordinates 1085811..1086209 (+) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YPZ3_RS04880 1080637..1082154 + 1518 WP_002209930.1 lysine--tRNA ligase -
YPZ3_RS04890 1082587..1083801 + 1215 WP_002209929.1 tyrosine-type recombinase/integrase -
YPZ3_RS04895 1083883..1084068 - 186 WP_002209928.1 hypothetical protein -
YPZ3_RS04905 1084666..1084926 + 261 WP_002214785.1 type II toxin-antitoxin system RelE/ParE family toxin -
YPZ3_RS04910 1084989..1085351 + 363 WP_002209925.1 helix-turn-helix domain-containing protein -
YPZ3_RS04915 1085515..1085811 + 297 WP_002214787.1 type II toxin-antitoxin system MqsR family toxin Toxin
YPZ3_RS04920 1085811..1086209 + 399 WP_002209924.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
YPZ3_RS04925 1086609..1088900 - 2292 WP_002209923.1 toprim domain-containing protein -
YPZ3_RS04930 1089200..1089526 + 327 WP_002209922.1 type II toxin-antitoxin system RelE/ParE family toxin -
YPZ3_RS24660 1089519..1089671 + 153 WP_002209921.1 hypothetical protein -
YPZ3_RS04940 1089685..1089885 - 201 WP_002209920.1 AlpA family transcriptional regulator -
YPZ3_RS04945 1090067..1090399 - 333 WP_002214791.1 hypothetical protein -
YPZ3_RS04950 1090405..1090641 - 237 WP_002214792.1 hypothetical protein -
YPZ3_RS04955 1090654..1091019 - 366 WP_002209919.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11319.12 Da        Isoelectric Point: 7.8810

>T24708 WP_002214787.1 NC_014029:1085515-1085811 [Yersinia pestis Z176003]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Download         Length: 297 bp

>T24708 NC_014029:1085515-1085811 [Yersinia pestis Z176003]
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGAATGTCTCGTTTAAGGAGATTTAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14657.17 Da        Isoelectric Point: 8.4923

>AT24708 WP_002209924.1 NC_014029:1085811-1086209 [Yersinia pestis Z176003]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Download         Length: 399 bp

>AT24708 NC_014029:1085811-1086209 [Yersinia pestis Z176003]
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1NW62

Antitoxin

Source ID Structure
AlphaFold DB Q666X1

References