Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 173834..174436 Replicon chromosome
Accession NZ_CP098210
Organism Escherichia coli strain Z0117EC0051

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag NBY17_RS00755 Protein ID WP_000897305.1
Coordinates 173834..174145 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NBY17_RS00760 Protein ID WP_000356395.1
Coordinates 174146..174436 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY17_RS00730 (168876) 168876..169313 + 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
NBY17_RS00735 (169358) 169358..170299 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
NBY17_RS00740 (170715) 170715..171602 + 888 Protein_142 hypothetical protein -
NBY17_RS00745 (171615) 171615..172529 + 915 WP_109553727.1 transposase -
NBY17_RS00750 (172697) 172697..173605 - 909 WP_001550353.1 alpha/beta hydrolase -
NBY17_RS00755 (173834) 173834..174145 + 312 WP_000897305.1 hypothetical protein Toxin
NBY17_RS00760 (174146) 174146..174436 + 291 WP_000356395.1 NadS family protein Antitoxin
NBY17_RS00765 (174521) 174521..174742 + 222 WP_001550354.1 hypothetical protein -
NBY17_RS00770 (174794) 174794..175072 + 279 WP_001315112.1 hypothetical protein -
NBY17_RS00775 (175491) 175491..175709 + 219 WP_001295676.1 CopG family transcriptional regulator -
NBY17_RS00780 (175928) 175928..176170 + 243 WP_001309881.1 CopG family transcriptional regulator -
NBY17_RS00785 (176352) 176352..177281 - 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
NBY17_RS00790 (177278) 177278..177913 - 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
NBY17_RS00795 (177910) 177910..178812 - 903 WP_000331377.1 formate dehydrogenase O subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T247075 WP_000897305.1 NZ_CP098210:173834-174145 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10869.46 Da        Isoelectric Point: 10.8907

>AT247075 WP_000356395.1 NZ_CP098210:174146-174436 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRHPSRTFEVDAMKIKEIRRASGLSQSKFAELISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References