Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4860161..4860763 Replicon chromosome
Accession NZ_CP098206
Organism Escherichia coli strain Z0117EC0054

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag NBY18_RS23785 Protein ID WP_000897302.1
Coordinates 4860452..4860763 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NBY18_RS23780 Protein ID WP_000356397.1
Coordinates 4860161..4860451 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY18_RS23755 (4856234) 4856234..4857136 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
NBY18_RS23760 (4857133) 4857133..4857768 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
NBY18_RS23765 (4857765) 4857765..4858694 + 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
NBY18_RS23770 (4858910) 4858910..4859128 - 219 WP_001314326.1 CopG family transcriptional regulator -
NBY18_RS23775 (4859524) 4859524..4859802 - 279 WP_001296612.1 hypothetical protein -
NBY18_RS23780 (4860161) 4860161..4860451 - 291 WP_000356397.1 NadS family protein Antitoxin
NBY18_RS23785 (4860452) 4860452..4860763 - 312 WP_000897302.1 hypothetical protein Toxin
NBY18_RS23790 (4860992) 4860992..4861900 + 909 WP_001331553.1 alpha/beta hydrolase -
NBY18_RS23795 (4861964) 4861964..4862905 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
NBY18_RS23800 (4862950) 4862950..4863387 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
NBY18_RS23805 (4863384) 4863384..4864256 - 873 WP_000920754.1 virulence factor BrkB family protein -
NBY18_RS23810 (4864250) 4864250..4864849 - 600 WP_001314324.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T247072 WP_000897302.1 NZ_CP098206:c4860763-4860452 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT247072 WP_000356397.1 NZ_CP098206:c4860451-4860161 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References