Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2611397..2611959 Replicon chromosome
Accession NZ_CP098206
Organism Escherichia coli strain Z0117EC0054

Toxin (Protein)


Gene name higB Uniprot ID S1Q1V8
Locus tag NBY18_RS12650 Protein ID WP_000605675.1
Coordinates 2611397..2611675 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag NBY18_RS12655 Protein ID WP_000781370.1
Coordinates 2611675..2611959 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY18_RS12625 (2606984) 2606984..2607415 - 432 WP_000152310.1 peroxiredoxin OsmC -
NBY18_RS12630 (2607760) 2607760..2607975 + 216 WP_000495766.1 biofilm-dependent modulation protein -
NBY18_RS12635 (2608077) 2608077..2608214 + 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
NBY18_RS12640 (2608370) 2608370..2610067 + 1698 WP_000433462.1 malate dehydrogenase -
NBY18_RS12645 (2610201) 2610201..2611211 + 1011 WP_000642412.1 alcohol dehydrogenase AdhP -
NBY18_RS12650 (2611397) 2611397..2611675 + 279 WP_000605675.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NBY18_RS12655 (2611675) 2611675..2611959 + 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
NBY18_RS12660 (2612188) 2612188..2612841 - 654 WP_000045647.1 formate dehydrogenase-N subunit gamma -
NBY18_RS12665 (2612834) 2612834..2613718 - 885 WP_001240584.1 formate dehydrogenase N subunit beta -
NBY18_RS12670 (2613731) 2613731..2616778 - 3048 WP_011478186.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10537.16 Da        Isoelectric Point: 7.3206

>T247064 WP_000605675.1 NZ_CP098206:2611397-2611675 [Escherichia coli]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAACCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT247064 WP_000781370.1 NZ_CP098206:2611675-2611959 [Escherichia coli]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1Q1V8

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References