Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2019811..2020313 Replicon chromosome
Accession NZ_CP098206
Organism Escherichia coli strain Z0117EC0054

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag NBY18_RS09810 Protein ID WP_000767822.1
Coordinates 2020059..2020313 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag NBY18_RS09805 Protein ID WP_001259255.1
Coordinates 2019811..2020062 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY18_RS09780 (2014989) 2014989..2016056 - 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
NBY18_RS09785 (2016056) 2016056..2017126 - 1071 WP_000108943.1 histidinol-phosphate transaminase -
NBY18_RS09790 (2017123) 2017123..2018427 - 1305 WP_001617113.1 histidinol dehydrogenase -
NBY18_RS09795 (2018433) 2018433..2019332 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
NBY18_RS09800 (2019478) 2019478..2019528 - 51 WP_001364200.1 his operon leader peptide -
NBY18_RS09805 (2019811) 2019811..2020062 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
NBY18_RS09810 (2020059) 2020059..2020313 + 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
NBY18_RS09815 (2020396) 2020396..2021220 + 825 WP_000754733.1 SDR family oxidoreductase -
NBY18_RS09820 (2021266) 2021266..2022195 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
NBY18_RS09825 (2022410) 2022410..2022472 + 63 WP_010723108.1 membrane protein YoeI -
NBY18_RS09830 (2022462) 2022462..2023820 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T247057 WP_000767822.1 NZ_CP098206:2020059-2020313 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT247057 WP_001259255.1 NZ_CP098206:2019811-2020062 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References