Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1912098..1912600 Replicon chromosome
Accession NZ_CP098203
Organism Escherichia coli strain Z0117EC0055

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag NBY19_RS08995 Protein ID WP_000767822.1
Coordinates 1912346..1912600 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag NBY19_RS08990 Protein ID WP_001259255.1
Coordinates 1912098..1912349 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY19_RS08965 (1907276) 1907276..1908343 - 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
NBY19_RS08970 (1908343) 1908343..1909413 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
NBY19_RS08975 (1909410) 1909410..1910714 - 1305 WP_001546022.1 histidinol dehydrogenase -
NBY19_RS08980 (1910720) 1910720..1911619 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
NBY19_RS08985 (1911765) 1911765..1911815 - 51 WP_001364200.1 his operon leader peptide -
NBY19_RS08990 (1912098) 1912098..1912349 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
NBY19_RS08995 (1912346) 1912346..1912600 + 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
NBY19_RS09000 (1912683) 1912683..1913507 + 825 WP_000754737.1 SDR family oxidoreductase -
NBY19_RS09005 (1913553) 1913553..1914482 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
NBY19_RS09010 (1914697) 1914697..1914759 + 63 WP_010723108.1 membrane protein YoeI -
NBY19_RS09015 (1914749) 1914749..1916107 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T247033 WP_000767822.1 NZ_CP098203:1912346-1912600 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT247033 WP_001259255.1 NZ_CP098203:1912098-1912349 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References