Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 644182..644981 Replicon chromosome
Accession NZ_CP098203
Organism Escherichia coli strain Z0117EC0055

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag NBY19_RS03170 Protein ID WP_000347251.1
Coordinates 644182..644646 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag NBY19_RS03175 Protein ID WP_001296435.1
Coordinates 644646..644981 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY19_RS03140 (639183) 639183..639617 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
NBY19_RS03145 (639635) 639635..640513 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
NBY19_RS03150 (640503) 640503..641282 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
NBY19_RS03155 (641293) 641293..641766 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
NBY19_RS03160 (641789) 641789..643069 - 1281 WP_000681950.1 tagatose-bisphosphate aldolase subunit KbaZ -
NBY19_RS03165 (643318) 643318..644127 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
NBY19_RS03170 (644182) 644182..644646 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
NBY19_RS03175 (644646) 644646..644981 - 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
NBY19_RS03180 (645130) 645130..646710 - 1581 WP_250844063.1 galactarate dehydratase -
NBY19_RS03185 (647085) 647085..648419 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
NBY19_RS03190 (648435) 648435..649205 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T247029 WP_000347251.1 NZ_CP098203:c644646-644182 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT247029 WP_001296435.1 NZ_CP098203:c644981-644646 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References