247027

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 227109..228427 Replicon chromosome
Accession NZ_CP098203
Organism Escherichia coli strain Z0117EC0055

Toxin (Protein)


Gene name HipT Uniprot ID F4T5A3
Locus tag NBY19_RS01085 Protein ID WP_001262467.1
Coordinates 227420..228427 (+) Length 336 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID F4T5A4
Locus tag NBY19_RS01080 Protein ID WP_001312177.1
Coordinates 227109..227420 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY19_RS01050 (222396) 222396..222623 - 228 WP_000198577.1 hypothetical protein -
NBY19_RS01055 (222641) 222641..223660 + 1020 WP_000938855.1 dipeptide ABC transporter permease DppB -
NBY19_RS01060 (223670) 223670..224572 + 903 WP_000084677.1 dipeptide ABC transporter permease DppC -
NBY19_RS01065 (224583) 224583..225566 + 984 WP_001196477.1 dipeptide ABC transporter ATP-binding protein -
NBY19_RS01070 (225563) 225563..226576 + 1014 WP_000103572.1 dipeptide ABC transporter ATP-binding subunit DppF -
NBY19_RS01075 (226801) 226801..227124 + 324 WP_000563102.1 helix-turn-helix transcriptional regulator -
NBY19_RS01080 (227109) 227109..227420 + 312 WP_001312177.1 HipA N-terminal domain-containing protein Antitoxin
NBY19_RS01085 (227420) 227420..228427 + 1008 WP_001262467.1 HipA domain-containing protein Toxin
NBY19_RS01090 (228444) 228444..229715 - 1272 WP_001545666.1 amino acid permease -
- (230077) 230077..230142 - 66 NuclAT_27 - -
- (230077) 230077..230142 - 66 NuclAT_27 - -
- (230077) 230077..230142 - 66 NuclAT_27 - -
- (230077) 230077..230142 - 66 NuclAT_27 - -
NBY19_RS01095 (230191) 230191..230298 + 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
- (230560) 230560..230617 - 58 NuclAT_26 - -
- (230560) 230560..230617 - 58 NuclAT_26 - -
- (230560) 230560..230617 - 58 NuclAT_26 - -
- (230560) 230560..230617 - 58 NuclAT_26 - -
NBY19_RS01100 (230674) 230674..230781 + 108 WP_000170748.1 type I toxin-antitoxin system toxin Ldr family protein -
NBY19_RS01105 (231157) 231157..231264 + 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
NBY19_RS01110 (231350) 231350..233029 - 1680 Protein_219 cellulose biosynthesis protein BcsG -
NBY19_RS01115 (233026) 233026..233217 - 192 WP_000988308.1 cellulose biosynthesis protein BcsF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-302)

Antitoxin

HipA, N-terminal subdomain 1

(6-98)


Sequences

Toxin        


Download         Length: 336 a.a.        Molecular weight: 38320.60 Da        Isoelectric Point: 5.5965

>T247027 WP_001262467.1 NZ_CP098203:227420-228427 [Escherichia coli]
MANCRILLTPLNERDEQRGYSTQGLKRLSGTAKLTPRLGFTRTQFVQELPRQQKGMSISGYQPKLQLVLDEGEFRVVDHQ
GNFILKPSPADFPGLAENEHATMTLMSRLGFDVPVHGLLSFAPQSEEELEYAFVIRRYDRDNKGLPVHQEQLDGAMQIMD
KYGKTGNDNEQYVSYETLARFLVAHVNDNIAFKIDLFRRIVYAWLLGNNDMHLRNFGLVYSDGLTPALAPVYDFVSVAPY
PEYFHSNYLALPLLTREEGGRELAPGFHSDYGEYIGQDFLLLGESMGLAPRLLEKLFQDIRKENAIVMETYEQSFMTQDH
IQAVLQCYRHRLGLL

Download         Length: 1008 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11821.47 Da        Isoelectric Point: 6.0609

>AT247027 WP_001312177.1 NZ_CP098203:227109-227420 [Escherichia coli]
MHRRVKVLLYGQVVGELSQNDSGFLFQYAPDYHGPAISISLPVAQRQFPSEMLHPYFASLAPEGWLRQRYSQIQHRDEND
LLGMLIDNGKNLLGAIQILPWEE

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3K2ZTB5

Antitoxin

Source ID Structure
AlphaFold DB A0A3L3HKE2

References