Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 160431..161033 Replicon chromosome
Accession NZ_CP098201
Organism Escherichia coli strain Z0117EC0056

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag NBY20_RS00780 Protein ID WP_000897305.1
Coordinates 160431..160742 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NBY20_RS00785 Protein ID WP_000356395.1
Coordinates 160743..161033 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY20_RS00755 (155473) 155473..155910 + 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
NBY20_RS00760 (155955) 155955..156896 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
NBY20_RS00765 (157312) 157312..158199 + 888 Protein_137 hypothetical protein -
NBY20_RS00770 (158212) 158212..159126 + 915 WP_109553727.1 transposase -
NBY20_RS00775 (159294) 159294..160202 - 909 WP_001550353.1 alpha/beta hydrolase -
NBY20_RS00780 (160431) 160431..160742 + 312 WP_000897305.1 hypothetical protein Toxin
NBY20_RS00785 (160743) 160743..161033 + 291 WP_000356395.1 NadS family protein Antitoxin
NBY20_RS00790 (161118) 161118..161339 + 222 WP_001550354.1 hypothetical protein -
NBY20_RS00795 (161391) 161391..161669 + 279 WP_001315112.1 hypothetical protein -
NBY20_RS00800 (162088) 162088..162306 + 219 WP_001295676.1 CopG family transcriptional regulator -
NBY20_RS00805 (162525) 162525..162767 + 243 WP_001309881.1 CopG family transcriptional regulator -
NBY20_RS00810 (162949) 162949..163878 - 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
NBY20_RS00815 (163875) 163875..164510 - 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
NBY20_RS00820 (164507) 164507..165409 - 903 WP_000331377.1 formate dehydrogenase O subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T247000 WP_000897305.1 NZ_CP098201:160431-160742 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10869.46 Da        Isoelectric Point: 10.8907

>AT247000 WP_000356395.1 NZ_CP098201:160743-161033 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRHPSRTFEVDAMKIKEIRRASGLSQSKFAELISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References