Detailed information of TA system TA246996

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 63457..63721
• Replicon: plasmid pZ0117EC0062-3
• Accession: NZ_CP098200
• Organism: Escherichia coli strain Z0117EC0062

Toxin (Protein)

• Gene name: pndA
• Uniprot ID: A0A8H9BDR8
• Locus tag: NBY21_RS25305
• Protein ID: WP_023156060.1
• Coordinates: 63569..63721 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	pndB
Locus tag	-
Coordinates	63457..63514 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NBY21_RS25290 (58570)	58570..59781	-	1212	WP_053285743.1	DsbC family protein	-
NBY21_RS25295 (59856)	59856..61049	-	1194	WP_250840887.1	hypothetical protein	-
NBY21_RS25300 (61065)	61065..63278	-	2214	WP_021560353.1	type IA DNA topoisomerase	-
- (63457)	63457..63514	-	58	NuclAT_0	-	Antitoxin
- (63457)	63457..63514	-	58	NuclAT_0	-	Antitoxin
- (63457)	63457..63514	-	58	NuclAT_0	-	Antitoxin
- (63457)	63457..63514	-	58	NuclAT_0	-	Antitoxin
NBY21_RS25305 (63569)	63569..63721	+	153	WP_023156060.1	Hok/Gef family protein	Toxin
NBY21_RS25310 (63793)	63793..64044	-	252	WP_001685192.1	hypothetical protein	-
NBY21_RS25515 (64359)	64359..64454	+	96	WP_000609149.1	DinQ-like type I toxin DqlB	-
NBY21_RS25320 (64560)	64560..65513	-	954	WP_141074322.1	hypothetical protein	-
NBY21_RS25325 (65582)	65582..67726	-	2145	WP_250840888.1	DotA/TraY family protein	-
NBY21_RS25330 (67761)	67761..67985	-	225	WP_021560350.1	hypothetical protein	-
NBY21_RS25335 (67988)	67988..68551	-	564	WP_021560349.1	conjugal transfer protein TraX	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..91127	91127

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (7-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5809.14 Da
• Isoelectric Point: 8.7948

>T246996 WP_023156060.1 NZ_CP098200:63569-63721 [Escherichia coli]
MPQRTFLMMLIVICVTILCFVWMVRDSLCGFRLQQGNTVLVATLAYEVKR

Nucleotide

• Length: 153 bp

Antitoxin

Nucleotide

• Length: 58 bp

>AT246996 NZ_CP098200:c63514-63457 [Escherichia coli]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Structures

Antitoxin