246989

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4844137..4844739 Replicon chromosome
Accession NZ_CP098197
Organism Escherichia coli strain Z0117EC0062

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag NBY21_RS23080 Protein ID WP_000897305.1
Coordinates 4844428..4844739 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NBY21_RS23075 Protein ID WP_000356395.1
Coordinates 4844137..4844427 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY21_RS23040 (4839761) 4839761..4840663 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
NBY21_RS23045 (4840660) 4840660..4841295 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
NBY21_RS23050 (4841292) 4841292..4842221 + 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
NBY21_RS23055 (4842403) 4842403..4842645 - 243 WP_001309881.1 CopG family transcriptional regulator -
NBY21_RS23060 (4842864) 4842864..4843082 - 219 WP_001295676.1 CopG family transcriptional regulator -
NBY21_RS23065 (4843501) 4843501..4843779 - 279 WP_001315112.1 hypothetical protein -
NBY21_RS23070 (4843831) 4843831..4844052 - 222 WP_001550354.1 hypothetical protein -
NBY21_RS23075 (4844137) 4844137..4844427 - 291 WP_000356395.1 NadS family protein Antitoxin
NBY21_RS23080 (4844428) 4844428..4844739 - 312 WP_000897305.1 hypothetical protein Toxin
NBY21_RS23085 (4844968) 4844968..4845876 + 909 WP_001550353.1 alpha/beta hydrolase -
NBY21_RS23090 (4846044) 4846044..4846958 - 915 WP_109553727.1 transposase -
NBY21_RS23095 (4846971) 4846971..4847858 - 888 Protein_4513 hypothetical protein -
NBY21_RS23100 (4848274) 4848274..4849215 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
NBY21_RS23105 (4849260) 4849260..4849697 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T246989 WP_000897305.1 NZ_CP098197:c4844739-4844428 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10869.46 Da        Isoelectric Point: 10.8907

>AT246989 WP_000356395.1 NZ_CP098197:c4844427-4844137 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRHPSRTFEVDAMKIKEIRRASGLSQSKFAELISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References