246981

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-istR/SymE(toxin)
Location 4284709..4285121 Replicon chromosome
Accession NZ_CP098197
Organism Escherichia coli strain Z0117EC0062

Toxin (Protein)


Gene name symE Uniprot ID U9YSY7
Locus tag NBY21_RS20425 Protein ID WP_000132601.1
Coordinates 4284780..4285121 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name istR
Locus tag -
Coordinates 4284709..4284785 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY21_RS20415 (4281572) 4281572..4283161 + 1590 WP_001063200.1 type I restriction-modification system methyltransferase -
NBY21_RS20420 (4283158) 4283158..4284552 + 1395 WP_001272445.1 type I restriction-modification system specificity subunit -
- (4284709) 4284709..4284785 - 77 NuclAT_10 - Antitoxin
- (4284709) 4284709..4284785 - 77 NuclAT_10 - Antitoxin
- (4284709) 4284709..4284785 - 77 NuclAT_10 - Antitoxin
- (4284709) 4284709..4284785 - 77 NuclAT_10 - Antitoxin
- (4284709) 4284709..4284785 - 77 NuclAT_9 - Antitoxin
- (4284709) 4284709..4284785 - 77 NuclAT_9 - Antitoxin
- (4284709) 4284709..4284785 - 77 NuclAT_9 - Antitoxin
- (4284709) 4284709..4284785 - 77 NuclAT_9 - Antitoxin
NBY21_RS20425 (4284780) 4284780..4285121 + 342 WP_000132601.1 endoribonuclease SymE Toxin
NBY21_RS20430 (4285283) 4285283..4286662 + 1380 WP_000443951.1 5-methylcytosine-specific restriction endonuclease subunit McrB -
NBY21_RS20435 (4286662) 4286662..4287708 + 1047 WP_000437621.1 5-methylcytosine-specific restriction endonuclease system specificity protein McrC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12203.02 Da        Isoelectric Point: 8.5012

>T246981 WP_000132601.1 NZ_CP098197:4284780-4285121 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Download         Length: 342 bp

Antitoxin


Download         Length: 77 bp

>AT246981 NZ_CP098197:c4284785-4284709 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YSY7

Antitoxin

Download structure file

References