Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 677405..678204 Replicon chromosome
Accession NZ_CP098197
Organism Escherichia coli strain Z0117EC0062

Toxin (Protein)


Gene name yhaV Uniprot ID F0JQM9
Locus tag NBY21_RS03340 Protein ID WP_000347270.1
Coordinates 677405..677869 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID A0A0V9H1L4
Locus tag NBY21_RS03345 Protein ID WP_001551693.1
Coordinates 677869..678204 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY21_RS03310 (672406) 672406..672840 - 435 WP_000948837.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
NBY21_RS03315 (672858) 672858..673736 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
NBY21_RS03320 (673726) 673726..674505 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
NBY21_RS03325 (674516) 674516..674989 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
NBY21_RS03330 (675012) 675012..676292 - 1281 WP_001551694.1 tagatose-bisphosphate aldolase subunit KbaZ -
NBY21_RS03335 (676541) 676541..677350 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
NBY21_RS03340 (677405) 677405..677869 - 465 WP_000347270.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
NBY21_RS03345 (677869) 677869..678204 - 336 WP_001551693.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
NBY21_RS03350 (678353) 678353..679924 - 1572 WP_001273738.1 galactarate dehydratase -
NBY21_RS03355 (680299) 680299..681633 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
NBY21_RS03360 (681649) 681649..682419 + 771 WP_001551692.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17806.22 Da        Isoelectric Point: 9.6924

>T246965 WP_000347270.1 NZ_CP098197:c677869-677405 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEEAH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12347.87 Da        Isoelectric Point: 4.6890

>AT246965 WP_001551693.1 NZ_CP098197:c678204-677869 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDTQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9NQ90

Antitoxin

Source ID Structure
AlphaFold DB A0A0V9H1L4

References