Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4875077..4875679 Replicon chromosome
Accession NZ_CP098195
Organism Escherichia coli strain Z0117EC0098

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag NBY23_RS23720 Protein ID WP_000897305.1
Coordinates 4875368..4875679 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NBY23_RS23715 Protein ID WP_000356397.1
Coordinates 4875077..4875367 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY23_RS23690 (4871002) 4871002..4871904 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
NBY23_RS23695 (4871901) 4871901..4872536 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
NBY23_RS23700 (4872533) 4872533..4873462 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
NBY23_RS23705 (4873792) 4873792..4874034 - 243 WP_001087409.1 protein YiiF -
NBY23_RS23710 (4874254) 4874254..4874472 - 219 WP_001315930.1 CopG family transcriptional regulator -
NBY23_RS23715 (4875077) 4875077..4875367 - 291 WP_000356397.1 NadS family protein Antitoxin
NBY23_RS23720 (4875368) 4875368..4875679 - 312 WP_000897305.1 hypothetical protein Toxin
NBY23_RS23725 (4875908) 4875908..4876816 + 909 WP_001162704.1 alpha/beta hydrolase -
NBY23_RS23730 (4876880) 4876880..4877821 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
NBY23_RS23735 (4877866) 4877866..4878303 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
NBY23_RS23740 (4878300) 4878300..4879172 - 873 WP_000920762.1 virulence factor BrkB family protein -
NBY23_RS23745 (4879166) 4879166..4879765 - 600 WP_001295269.1 glucose-1-phosphatase -
NBY23_RS23750 (4879864) 4879864..4880649 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T246959 WP_000897305.1 NZ_CP098195:c4875679-4875368 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT246959 WP_000356397.1 NZ_CP098195:c4875367-4875077 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References