Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 4006350..4006891 Replicon chromosome
Accession NZ_CP098195
Organism Escherichia coli strain Z0117EC0098

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag NBY23_RS19740 Protein ID WP_000615976.1
Coordinates 4006613..4006891 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag NBY23_RS19735 Protein ID WP_000729704.1
Coordinates 4006350..4006610 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY23_RS19710 (4002133) 4002133..4002918 - 786 WP_000207575.1 putative lateral flagellar export/assembly protein LafU -
NBY23_RS19715 (4002890) 4002890..4004602 + 1713 Protein_3873 flagellar biosynthesis protein FlhA -
NBY23_RS19720 (4004707) 4004707..4004985 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
NBY23_RS19725 (4004978) 4004978..4005334 + 357 WP_001030483.1 type II toxin-antitoxin system HicB family antitoxin -
NBY23_RS19730 (4005391) 4005391..4006164 - 774 WP_000543895.1 C40 family peptidase -
NBY23_RS19735 (4006350) 4006350..4006610 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
NBY23_RS19740 (4006613) 4006613..4006891 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
NBY23_RS19745 (4007047) 4007047..4007787 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
NBY23_RS19750 (4007758) 4007758..4008525 - 768 WP_000333380.1 class II glutamine amidotransferase -
NBY23_RS19755 (4008731) 4008731..4009309 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - gmhA/lpcA / tssA / tssM / hcp1/tssD1 4004978..4030740 25762


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T246956 WP_000615976.1 NZ_CP098195:4006613-4006891 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT246956 WP_000729704.1 NZ_CP098195:4006350-4006610 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References