Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 756442..757241 Replicon chromosome
Accession NZ_CP098195
Organism Escherichia coli strain Z0117EC0098

Toxin (Protein)


Gene name yhaV Uniprot ID F4VJD3
Locus tag NBY23_RS03755 Protein ID WP_000347266.1
Coordinates 756442..756906 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag NBY23_RS03760 Protein ID WP_001307405.1
Coordinates 756906..757241 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY23_RS03725 (751443) 751443..751877 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
NBY23_RS03730 (751895) 751895..752773 - 879 WP_001315856.1 PTS N-acetylgalactosamine transporter subunit IID -
NBY23_RS03735 (752763) 752763..753542 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
NBY23_RS03740 (753553) 753553..754026 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
NBY23_RS03745 (754049) 754049..755329 - 1281 WP_000681921.1 tagatose-bisphosphate aldolase subunit KbaZ -
NBY23_RS03750 (755578) 755578..756387 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
NBY23_RS03755 (756442) 756442..756906 - 465 WP_000347266.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
NBY23_RS03760 (756906) 756906..757241 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
NBY23_RS03765 (757390) 757390..758961 - 1572 WP_001273741.1 galactarate dehydratase -
NBY23_RS03770 (759336) 759336..760670 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
NBY23_RS03775 (760686) 760686..761456 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17841.18 Da        Isoelectric Point: 9.4947

>T246939 WP_000347266.1 NZ_CP098195:c756906-756442 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRFFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT246939 WP_001307405.1 NZ_CP098195:c757241-756906 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A836NGD2

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References