Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 647931..648730 Replicon chromosome
Accession NZ_CP098192
Organism Escherichia coli strain Z0117EC0116

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag NBY24_RS03155 Protein ID WP_000347251.1
Coordinates 647931..648395 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag NBY24_RS03160 Protein ID WP_001307405.1
Coordinates 648395..648730 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY24_RS03125 (642932) 642932..643366 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
NBY24_RS03130 (643384) 643384..644262 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
NBY24_RS03135 (644252) 644252..645031 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
NBY24_RS03140 (645042) 645042..645515 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
NBY24_RS03145 (645538) 645538..646818 - 1281 WP_000681904.1 tagatose-bisphosphate aldolase subunit KbaZ -
NBY24_RS03150 (647067) 647067..647876 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
NBY24_RS03155 (647931) 647931..648395 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
NBY24_RS03160 (648395) 648395..648730 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
NBY24_RS03165 (648879) 648879..650450 - 1572 WP_001273748.1 galactarate dehydratase -
NBY24_RS03170 (650825) 650825..652159 + 1335 WP_000599653.1 galactarate/glucarate/glycerate transporter GarP -
NBY24_RS03175 (652175) 652175..652945 + 771 WP_001058214.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T246907 WP_000347251.1 NZ_CP098192:c648395-647931 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT246907 WP_001307405.1 NZ_CP098192:c648730-648395 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References