Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3216129..3216631 Replicon chromosome
Accession NZ_CP098187
Organism Escherichia coli strain Z0117EC0117

Toxin (Protein)


Gene name yoeB Uniprot ID D8A584
Locus tag NBY25_RS15840 Protein ID WP_000767828.1
Coordinates 3216129..3216383 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag NBY25_RS15845 Protein ID WP_001259255.1
Coordinates 3216380..3216631 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY25_RS15810 (3211144) 3211144..3211371 - 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -
NBY25_RS15815 (3211385) 3211385..3212443 - 1059 WP_000492324.1 thiosulfate utilization transporter TsuA/YeeE -
NBY25_RS15820 (3212622) 3212622..3213980 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
NBY25_RS15825 (3213970) 3213970..3214032 - 63 WP_010723108.1 membrane protein YoeI -
NBY25_RS15830 (3214247) 3214247..3215176 - 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
NBY25_RS15835 (3215222) 3215222..3216046 - 825 WP_000754740.1 SDR family oxidoreductase -
NBY25_RS15840 (3216129) 3216129..3216383 - 255 WP_000767828.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
NBY25_RS15845 (3216380) 3216380..3216631 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
NBY25_RS15850 (3216914) 3216914..3216964 + 51 WP_001364200.1 his operon leader peptide -
NBY25_RS15855 (3217110) 3217110..3218009 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
NBY25_RS15860 (3218015) 3218015..3219319 + 1305 WP_001370829.1 histidinol dehydrogenase -
NBY25_RS15865 (3219316) 3219316..3220386 + 1071 WP_000108949.1 histidinol-phosphate transaminase -
NBY25_RS15870 (3220386) 3220386..3221453 + 1068 WP_000080129.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10169.56 Da        Isoelectric Point: 8.0353

>T246895 WP_000767828.1 NZ_CP098187:c3216383-3216129 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEDHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT246895 WP_001259255.1 NZ_CP098187:c3216631-3216380 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829G465

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References