Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2547138..2547700 Replicon chromosome
Accession NZ_CP098187
Organism Escherichia coli strain Z0117EC0117

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NBY25_RS12535 Protein ID WP_250782040.1
Coordinates 2547422..2547700 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag NBY25_RS12530 Protein ID WP_000781370.1
Coordinates 2547138..2547422 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY25_RS12515 (2542319) 2542319..2545366 + 3048 WP_077634457.1 formate dehydrogenase-N subunit alpha -
NBY25_RS12520 (2545379) 2545379..2546263 + 885 WP_001240584.1 formate dehydrogenase N subunit beta -
NBY25_RS12525 (2546256) 2546256..2546909 + 654 WP_000045647.1 formate dehydrogenase-N subunit gamma -
NBY25_RS12530 (2547138) 2547138..2547422 - 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
NBY25_RS12535 (2547422) 2547422..2547700 - 279 WP_250782040.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NBY25_RS12540 (2547886) 2547886..2548896 - 1011 WP_000642412.1 alcohol dehydrogenase AdhP -
NBY25_RS12545 (2549029) 2549029..2550726 - 1698 WP_000433462.1 malate dehydrogenase -
NBY25_RS12550 (2550882) 2550882..2551019 - 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
NBY25_RS12555 (2551121) 2551121..2551336 - 216 WP_000495766.1 biofilm-dependent modulation protein -
NBY25_RS12560 (2551681) 2551681..2552112 + 432 WP_000152305.1 peroxiredoxin OsmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10565.22 Da        Isoelectric Point: 7.3206

>T246889 WP_250782040.1 NZ_CP098187:c2547700-2547422 [Escherichia coli]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAACCLADIDMPGYRLHPLSGDRDGIWVISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT246889 WP_000781370.1 NZ_CP098187:c2547422-2547138 [Escherichia coli]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References