Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 976124..976665 Replicon chromosome
Accession NZ_CP098183
Organism Escherichia coli strain Z0117EC0133

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag NBY27_RS04505 Protein ID WP_000615976.1
Coordinates 976124..976402 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag NBY27_RS04510 Protein ID WP_000729704.1
Coordinates 976405..976665 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY27_RS04490 (973706) 973706..974284 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
NBY27_RS04495 (974490) 974490..975257 + 768 WP_000333380.1 class II glutamine amidotransferase -
NBY27_RS04500 (975228) 975228..975968 - 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
NBY27_RS04505 (976124) 976124..976402 - 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
NBY27_RS04510 (976405) 976405..976665 - 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
NBY27_RS04515 (976851) 976851..977624 + 774 WP_000543899.1 C40 family peptidase -
NBY27_RS04520 (977681) 977681..978037 - 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
NBY27_RS04525 (978030) 978030..978308 - 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
NBY27_RS04530 (978413) 978413..980125 - 1713 Protein_867 flagellar biosynthesis protein FlhA -
NBY27_RS04535 (980097) 980097..980882 + 786 WP_000207568.1 putative lateral flagellar export/assembly protein LafU -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T246858 WP_000615976.1 NZ_CP098183:c976402-976124 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT246858 WP_000729704.1 NZ_CP098183:c976665-976405 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References