Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 156886..157488 Replicon chromosome
Accession NZ_CP098183
Organism Escherichia coli strain Z0117EC0133

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag NBY27_RS00760 Protein ID WP_000897305.1
Coordinates 156886..157197 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NBY27_RS00765 Protein ID WP_000356397.1
Coordinates 157198..157488 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY27_RS00730 (151916) 151916..152701 + 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -
NBY27_RS00735 (152800) 152800..153399 + 600 WP_240761453.1 glucose-1-phosphatase -
NBY27_RS00740 (153393) 153393..154265 + 873 WP_000920762.1 virulence factor BrkB family protein -
NBY27_RS00745 (154262) 154262..154699 + 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
NBY27_RS00750 (154744) 154744..155685 + 942 WP_001343389.1 fatty acid biosynthesis protein FabY -
NBY27_RS00755 (155749) 155749..156657 - 909 WP_001162704.1 alpha/beta hydrolase -
NBY27_RS00760 (156886) 156886..157197 + 312 WP_000897305.1 hypothetical protein Toxin
NBY27_RS00765 (157198) 157198..157488 + 291 WP_000356397.1 NadS family protein Antitoxin
NBY27_RS00770 (158093) 158093..158311 + 219 WP_001297075.1 CopG family transcriptional regulator -
NBY27_RS00775 (158530) 158530..158772 + 243 WP_001086388.1 protein YiiF -
NBY27_RS00780 (159102) 159102..160031 - 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
NBY27_RS00785 (160028) 160028..160663 - 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
NBY27_RS00790 (160660) 160660..161562 - 903 WP_000331377.1 formate dehydrogenase O subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T246855 WP_000897305.1 NZ_CP098183:156886-157197 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT246855 WP_000356397.1 NZ_CP098183:157198-157488 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References