Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 996845..997386 Replicon chromosome
Accession NZ_CP098178
Organism Escherichia coli strain Z0117EC0148

Toxin (Protein)


Gene name yafQ Uniprot ID E9TC49
Locus tag NBY28_RS04700 Protein ID WP_000615982.1
Coordinates 996845..997123 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag NBY28_RS04705 Protein ID WP_000729704.1
Coordinates 997126..997386 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY28_RS04685 (994427) 994427..995005 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
NBY28_RS04690 (995211) 995211..995978 + 768 WP_000333380.1 class II glutamine amidotransferase -
NBY28_RS04695 (995949) 995949..996689 - 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
NBY28_RS04700 (996845) 996845..997123 - 279 WP_000615982.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
NBY28_RS04705 (997126) 997126..997386 - 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
NBY28_RS04710 (997572) 997572..998345 + 774 WP_000543899.1 C40 family peptidase -
NBY28_RS04715 (998402) 998402..998758 - 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
NBY28_RS04720 (998751) 998751..999029 - 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
NBY28_RS04725 (999134) 999134..1000846 - 1713 Protein_905 flagellar biosynthesis protein FlhA -
NBY28_RS04730 (1000818) 1000818..1001603 + 786 WP_000207575.1 putative lateral flagellar export/assembly protein LafU -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10816.59 Da        Isoelectric Point: 10.0702

>T246823 WP_000615982.1 NZ_CP098178:c997123-996845 [Escherichia coli]
MIQRDIEYSGQFSKDVKVAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT246823 WP_000729704.1 NZ_CP098178:c997386-997126 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References