Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 157776..158378 Replicon chromosome
Accession NZ_CP098178
Organism Escherichia coli strain Z0117EC0148

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag NBY28_RS00765 Protein ID WP_000897305.1
Coordinates 157776..158087 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NBY28_RS00770 Protein ID WP_000356397.1
Coordinates 158088..158378 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY28_RS00735 (152806) 152806..153591 + 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -
NBY28_RS00740 (153690) 153690..154289 + 600 WP_001295269.1 glucose-1-phosphatase -
NBY28_RS00745 (154283) 154283..155155 + 873 WP_000920762.1 virulence factor BrkB family protein -
NBY28_RS00750 (155152) 155152..155589 + 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
NBY28_RS00755 (155634) 155634..156575 + 942 WP_001343389.1 fatty acid biosynthesis protein FabY -
NBY28_RS00760 (156639) 156639..157547 - 909 WP_001162704.1 alpha/beta hydrolase -
NBY28_RS00765 (157776) 157776..158087 + 312 WP_000897305.1 hypothetical protein Toxin
NBY28_RS00770 (158088) 158088..158378 + 291 WP_000356397.1 NadS family protein Antitoxin
NBY28_RS00775 (158983) 158983..159201 + 219 WP_001295676.1 CopG family transcriptional regulator -
NBY28_RS00780 (159420) 159420..159662 + 243 WP_001086388.1 protein YiiF -
NBY28_RS00785 (159992) 159992..160921 - 930 WP_001749031.1 formate dehydrogenase accessory protein FdhE -
NBY28_RS00790 (160918) 160918..161553 - 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
NBY28_RS00795 (161550) 161550..162452 - 903 WP_000331377.1 formate dehydrogenase O subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T246821 WP_000897305.1 NZ_CP098178:157776-158087 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT246821 WP_000356397.1 NZ_CP098178:158088-158378 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References