Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4813140..4813786 Replicon chromosome
Accession NZ_CP098175
Organism Klebsiella pneumoniae strain Z0117KP0001

Toxin (Protein)


Gene name higB Uniprot ID W9BBY1
Locus tag NBY29_RS23635 Protein ID WP_016529833.1
Coordinates 4813439..4813786 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag NBY29_RS23630 Protein ID WP_002920557.1
Coordinates 4813140..4813439 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY29_RS23610 (4809346) 4809346..4810104 - 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -
NBY29_RS23615 (4810154) 4810154..4810984 - 831 WP_024622927.1 rhomboid family intramembrane serine protease GlpG -
NBY29_RS23620 (4811035) 4811035..4811364 - 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
NBY29_RS23625 (4811569) 4811569..4813077 + 1509 WP_023301456.1 glycerol-3-phosphate dehydrogenase -
NBY29_RS23630 (4813140) 4813140..4813439 - 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
NBY29_RS23635 (4813439) 4813439..4813786 - 348 WP_016529833.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NBY29_RS23640 (4813962) 4813962..4816409 - 2448 WP_002920561.1 glycogen phosphorylase -
NBY29_RS23645 (4816427) 4816427..4817860 - 1434 WP_002920564.1 glycogen synthase GlgA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13549.56 Da        Isoelectric Point: 5.6749

>T246818 WP_016529833.1 NZ_CP098175:c4813786-4813439 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT246818 WP_002920557.1 NZ_CP098175:c4813439-4813140 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W9BBY1

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References