Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3190073..3190331 Replicon chromosome
Accession NC_013961
Organism Erwinia amylovora CFBP1430

Toxin (Protein)


Gene name hok Uniprot ID D4I1C1
Locus tag EAMY_RS35380 Protein ID WP_004160031.1
Coordinates 3190073..3190231 (-) Length 53 a.a.

Antitoxin (RNA)


Gene name sok
Locus tag -
Coordinates 3190285..3190331 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EAMY_RS31565 3185378..3187069 - 1692 WP_004160025.1 chloride channel protein -
EAMY_RS31570 3187482..3188462 + 981 WP_013035818.1 TerC family protein -
EAMY_RS31575 3188697..3189929 + 1233 WP_004167257.1 serine/threonine transporter SstT -
EAMY_RS35380 3190073..3190231 - 159 WP_004160031.1 type I toxin-antitoxin system Hok family toxin Toxin
- 3190285..3190331 + 47 - - Antitoxin
EAMY_RS31580 3191042..3191716 + 675 WP_004160034.1 DedA family protein -
EAMY_RS31585 3191713..3192105 + 393 WP_004160035.1 EnvZ/OmpR regulon moderator MzrA -
EAMY_RS31590 3192273..3192644 + 372 WP_004160036.1 DUF1090 domain-containing protein -
EAMY_RS31595 3192687..3192992 + 306 WP_004160037.1 DUF883 family protein -
EAMY_RS31600 3192994..3193386 + 393 WP_004160038.1 phage holin family protein -
EAMY_RS31605 3193386..3193667 + 282 WP_004160039.1 YqjK-like family protein -
EAMY_RS31610 3193877..3194269 + 393 WP_004160048.1 DoxX family protein -
EAMY_RS36435 3194742..3194885 + 144 WP_004160049.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(8-48)


Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 6038.32 Da        Isoelectric Point: 8.4901

>T24680 WP_004160031.1 NC_013961:c3190231-3190073 [Erwinia amylovora CFBP1430]
MKLPANCLIWCVLIVCVTLLIFTYLTRKSLCEIRYKDGYREVAAFMAYESGK

Download         Length: 159 bp

>T24680 NC_013961:c3190231-3190073 [Erwinia amylovora CFBP1430]
ATGAAACTGCCAGCGAACTGTCTTATCTGGTGCGTACTTATAGTGTGTGTCACGCTTTTAATATTCACATATCTGACACG
AAAATCGCTCTGCGAAATTCGCTATAAGGATGGTTACAGGGAGGTGGCCGCTTTCATGGCTTACGAATCCGGCAAGTAG

Antitoxin


Download         Length: 47 bp

>AT24680 NC_013961:3190285-3190331 [Erwinia amylovora CFBP1430]
GCATGCAGATGGCCTCGTGGATTAATGAAAATTAACTACGGGGCTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A831A7I1

Antitoxin

Download structure file

References