Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 357703..358289 Replicon chromosome
Accession NZ_CP098167
Organism Klebsiella pneumoniae strain Z0117KP0004

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag NBY32_RS01680 Protein ID WP_002920800.1
Coordinates 357921..358289 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag NBY32_RS01675 Protein ID WP_004174006.1
Coordinates 357703..357924 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY32_RS01655 (353860) 353860..354786 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
NBY32_RS01660 (354783) 354783..356060 + 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
NBY32_RS01665 (356057) 356057..356824 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
NBY32_RS01670 (356826) 356826..357539 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
NBY32_RS01675 (357703) 357703..357924 + 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NBY32_RS01680 (357921) 357921..358289 + 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
NBY32_RS01685 (358562) 358562..359878 + 1317 WP_004174008.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
NBY32_RS01690 (359985) 359985..360872 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
NBY32_RS01695 (360869) 360869..361714 + 846 WP_032434559.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
NBY32_RS01700 (361716) 361716..362786 + 1071 WP_004150074.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 354783..363523 8740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T246773 WP_002920800.1 NZ_CP098167:357921-358289 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT246773 WP_004174006.1 NZ_CP098167:357703-357924 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References